Calcium Signalling: Intracellular calcium dynamics is highly organized in time and space. We focus on the molecular mechanisms responsible for this organization, which allows calcium to serve as a universal second messenger. Particular emphasis is put on the role of cellular calcium signalling in health...
The composition of microbial communities is dynamic: The relative abundances of species within a community vary with time and change with environmental conditions. We are developing mathematical and computational models to study the response of such microbial communities to environmental perturbations or to explain the...
Hematopoiesis is the process by which the various cell types in the blood are replenished through a complex hierarchical architecture of differentiating premature cells, initiated by rare and slowly reproducing stem cells in the bone marrow. Understanding this structure and how it is regulated is...
Metastasis is an inefficient process, with huge amounts of cancerous cells leaving the primary tumor but very few successfully seeding a distant malignant lesion. While it is clear that the microenvironment of the ectopic site plays an important role in debilitating an invading cell’s success,...
My motivation comes from identifying patterns and design principles in biological systems. My main projects include building dynamical models of microbial communities, studying neural induction during early embryogenesis of Ciona Intestinalis (collaboration with Yasuo Hitoyoshi's CNRS lab and Geneviève Dupont at ULB), and setting the...