Nanobodies have remarkable properties in terms of stability, solubility, high selectivity and specificity towards their targets. This makes them powerful tools in a wide series of biomedical and biotechnological applications that range from the design of tumor-targeted therapies to nanoscale detection. The project aims to...
Communication is essential at all biological scales. Our cells have been rigged with communication systems that allow them to respond properly to environmental cues. These systems, or signaling pathways, are composed of different proteins, whose activity is regulated by other proteins. This intricate regulatory system...
We are exploring how we can use our approaches to improve the detection of protein function and homology in their 'biophysical' instead of their sequence space. People Gabriele Orlando, Daniele Raimondi, Pathmanaban Ramasamy, Wim Vranken Extra information http://bio2byte.be/research/4...
We recently developed the DEOGEN approach, which predicts whether a particular amino acid variant in a human protein is likely to cause disease in the person carrying that mutation in their genetic material. The advantage of our approach is that we try to 'contextualise' the...
Most methods that predict per-residue characteristics from sequence are trained on information from in silico protein structures, which do not necessarily capture how the protein behaves in solution (e.g. helix fraying, loop movements). We are developing prediction approaches that are based on estimations of dynamics...