Seminars

Heterogeneity in cancer is a consequence of both irreversible genetic changes and reversible transcriptional changes. Melanoma is prime example for this since on the genomic level melanomas have a high mutational burden leading to inter and intra-tumor heterogeneity while on the transcriptomic level they can...

Abstract: Understanding how cells position themselves correctly in multicellular environments is a fundamental challenge in developmental biology. We use the invariable embryogenesis of C. elegans and a modelling approach to better understand the underlying mechanisms driving cellular movements. We developed a simulator to model the...