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Seminar Zeynep Kalender Atak, Heterogeneity of melanoma genomes and cell states (KUL)
March 15 @ 15 h 00 min - 16 h 00 min
Heterogeneity in cancer is a consequence of both irreversible genetic changes and reversible transcriptional changes. Melanoma is prime example for this since on the genomic level melanomas have a high mutational burden leading to inter and intra-tumor heterogeneity while on the transcriptomic level they can be classified into two distinct but highly plastic transcriptional states (termed as proliferative and invasive) leading to intra-tumor heterogeneity. These states potentially play a role in metastasis, therapy resistance and immune evasion, thus understanding the mechanisms of this transcriptional plasticity is crucial. In my talk, I will present our efforts for identifying molecular characteristics of these states using multi-omics approaches ranging from whole genome sequencing to bulk & single-cell transcriptome sequencing.