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BEGIN:VEVENT
DTSTART;TZID=Europe/Brussels:20260417T120000
DTEND;TZID=Europe/Brussels:20260417T140000
DTSTAMP:20260418T185107
CREATED:20260318T104843Z
LAST-MODIFIED:20260318T105356Z
UID:1901-1776427200-1776434400@ibsquare.be
SUMMARY:Journal Club - Ahmed Atmani
DESCRIPTION:Join us on Friday 17/04 at 12:00 for a Journal Club in the IB² seminar room (Campus La Plaine\, building BC\, hallway C\, 6th floor\, room 1C6.111). \n🔍 Presentation:\nTruong 2025: Understanding protein function with a multimodal retrieval-augmented foundation model – Ahmed Atmani  \n🥪 Please choose your sandwich before Thursday 16/04\, 12:00:\nhttps://docs.google.com/document/d/1gX2ZYMuOZGYYY9o6aLbJ9_GsB2-MrnK-UEAD3fpq5zE/edit?tab=t.0 \nWe hope to see you there!
URL:https://ibsquare.be/event/journal-club-ahmed-atmani/
LOCATION:(IB)² common room\, 1C6.111 - Building B/C\, 6th floor\, La Plaine Campus\, ULB
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Brussels:20260410T120000
DTEND;TZID=Europe/Brussels:20260410T140000
DTSTAMP:20260418T185107
CREATED:20260318T104506Z
LAST-MODIFIED:20260318T105403Z
UID:1899-1775822400-1775829600@ibsquare.be
SUMMARY:Journal Club - Noor Sioen
DESCRIPTION:Join us on Friday 10/04 at 12:00 for a Journal Club in the IB² seminar room (Campus La Plaine\, building BC\, hallway C\, 6th floor\, room 1C6.111). \n🔍 Presentation:\nNyssen 2011: Effect of beaver dams on the hydrology of small mountain streams: Example from the Chevral in the Ourthe Orientale basin\, Ardennes\, Belgium – Noor Sioen \n🥪 Please choose your sandwich before Thursday 09/04\, 12:00:\nhttps://docs.google.com/document/d/1gX2ZYMuOZGYYY9o6aLbJ9_GsB2-MrnK-UEAD3fpq5zE/edit?tab=t.0 \nWe hope to see you there!
URL:https://ibsquare.be/event/journal-club-noor-sioen/
LOCATION:(IB)² common room\, 1C6.111 - Building B/C\, 6th floor\, La Plaine Campus\, ULB
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Brussels:20260320T120000
DTEND;TZID=Europe/Brussels:20260320T140000
DTSTAMP:20260418T185107
CREATED:20260318T103141Z
LAST-MODIFIED:20260318T103141Z
UID:1896-1774008000-1774015200@ibsquare.be
SUMMARY:Journal Club - Benjamin Li
DESCRIPTION:Join us this Friday for a Journal Club in the IB² seminar room (Campus La Plaine\, building BC\, hallway C\, 6th floor\, room 1C6.111). \n🔍 Presentation:\nDauparas 2022: Robust deep learning–based protein sequence design using ProteinMPNN  (Benjamin Li) \n🥪 Please choose your sandwich before Thursday 19/03\, 12:00:\nhttps://docs.google.com/document/d/1gX2ZYMuOZGYYY9o6aLbJ9_GsB2-MrnK-UEAD3fpq5zE/edit?tab=t.0 \nWe hope to see you there!
URL:https://ibsquare.be/event/journal-club-benjamin-li/
LOCATION:(IB)² common room\, 1C6.111 - Building B/C\, 6th floor\, La Plaine Campus\, ULB
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Brussels:20240126T120000
DTEND;TZID=Europe/Brussels:20240126T140000
DTSTAMP:20260418T185107
CREATED:20260318T132727Z
LAST-MODIFIED:20260318T132727Z
UID:1909-1706270400-1706277600@ibsquare.be
SUMMARY:Journal Club - Charlotte Nachtegael
DESCRIPTION:🔍 Presentation: eMIND: Enabling automatic collection of protein variation impacts in Alzheimer’s disease from the literature – Charlotte Nachtegael  \nhttps://www.biorxiv.org/content/10.1101/2023.09.07.556602v1  \n 
URL:https://ibsquare.be/event/journal-club-charlotte-nachtegael-2/
LOCATION:(IB)² common room\, 1C6.111 - Building B/C\, 6th floor\, La Plaine Campus\, ULB
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Brussels:20240119T120000
DTEND;TZID=Europe/Brussels:20240119T140000
DTSTAMP:20260418T185107
CREATED:20260318T132419Z
LAST-MODIFIED:20260318T132419Z
UID:1907-1705665600-1705672800@ibsquare.be
SUMMARY:Journal Club - Barbara Gravel
DESCRIPTION:🔍 Presentation: Accurate proteome-wide missense variant effect prediction with Alpha Missense – Barbara Gravel 
URL:https://ibsquare.be/event/journal-club-barbara-gravel-3/
LOCATION:(IB)² common room\, 1C6.111 - Building B/C\, 6th floor\, La Plaine Campus\, ULB
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Brussels:20231124T120000
DTEND;TZID=Europe/Brussels:20231124T140000
DTSTAMP:20260418T185107
CREATED:20260318T132206Z
LAST-MODIFIED:20260318T132206Z
UID:1905-1700827200-1700834400@ibsquare.be
SUMMARY:Journal Club - Konstantina Tzavella
DESCRIPTION:🔍Presentation: Genome interpretation in a federated learning context allows the multi‑center exome‑based risk prediction of Crohn’s disease patients – Konstantina Tzavella
URL:https://ibsquare.be/event/journal-club-konstantina-tzavella-3/
LOCATION:(IB)² common room\, 1C6.111 - Building B/C\, 6th floor\, La Plaine Campus\, ULB
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Brussels:20230616T120000
DTEND;TZID=Europe/Brussels:20230616T130000
DTSTAMP:20260418T185107
CREATED:20221129T092126Z
LAST-MODIFIED:20260318T102336Z
UID:1672-1686916800-1686920400@ibsquare.be
SUMMARY:Journal Club - Charlotte Crauwels
DESCRIPTION:(IB)^2 common room 1C6.111 – Building B/C\, 6th floor\, La Plaine Campus\, ULB
URL:https://ibsquare.be/event/journal-club-charlotte-crauwels/
LOCATION:(IB)² common room\, 1C6.111 - Building B/C\, 6th floor\, La Plaine Campus\, ULB
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Brussels:20230602T120000
DTEND;TZID=Europe/Brussels:20230602T130000
DTSTAMP:20260418T185107
CREATED:20221129T092050Z
LAST-MODIFIED:20260318T102350Z
UID:1670-1685707200-1685710800@ibsquare.be
SUMMARY:Journal Club - Emma Verkinderen
DESCRIPTION:(IB)^2 common room 1C6.111 – Building B/C\, 6th floor\, La Plaine Campus\, ULB
URL:https://ibsquare.be/event/journal-club-emma-verkinderen/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Brussels:20230519T120000
DTEND;TZID=Europe/Brussels:20230519T130000
DTSTAMP:20260418T185107
CREATED:20221129T092017Z
LAST-MODIFIED:20260318T102407Z
UID:1668-1684497600-1684501200@ibsquare.be
SUMMARY:Journal Club - Sylvie Vande Velde
DESCRIPTION:(IB)^2 common room 1C6.111 – Building B/C\, 6th floor\, La Plaine Campus\, ULB
URL:https://ibsquare.be/event/journal-club-sylvie-vande-velde-2/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Brussels:20230505T120000
DTEND;TZID=Europe/Brussels:20230505T130000
DTSTAMP:20260418T185107
CREATED:20221129T091938Z
LAST-MODIFIED:20260318T130122Z
UID:1666-1683288000-1683291600@ibsquare.be
SUMMARY:Journal Club - Sofia Papadimitriou
DESCRIPTION:(IB)^2 common room 1C6.111 – Building B/C\, 6th floor\, La Plaine Campus\, ULB
URL:https://ibsquare.be/event/journal-club-sofia-papadimitriou/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Brussels:20230421T120000
DTEND;TZID=Europe/Brussels:20230421T130000
DTSTAMP:20260418T185107
CREATED:20221129T091904Z
LAST-MODIFIED:20260318T130130Z
UID:1664-1682078400-1682082000@ibsquare.be
SUMMARY:Journal Club - Alexandre Renaux
DESCRIPTION:(IB)^2 common room 1C6.111 – Building B/C\, 6th floor\, La Plaine Campus\, ULB
URL:https://ibsquare.be/event/journal-club-alexandre-renaux/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Brussels:20230331T120000
DTEND;TZID=Europe/Brussels:20230331T130000
DTSTAMP:20260418T185107
CREATED:20221129T091812Z
LAST-MODIFIED:20260318T130137Z
UID:1662-1680264000-1680267600@ibsquare.be
SUMMARY:Journal Club - David Bickel
DESCRIPTION:(IB)^2 common room 1C6.111 – Building B/C\, 6th floor\, La Plaine Campus\, ULB
URL:https://ibsquare.be/event/journal-club-david-bickel/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Brussels:20230317T120000
DTEND;TZID=Europe/Brussels:20230317T130000
DTSTAMP:20260418T185107
CREATED:20221129T091734Z
LAST-MODIFIED:20260318T130146Z
UID:1660-1679054400-1679058000@ibsquare.be
SUMMARY:Journal Club - Jose Gavalda-Garcia
DESCRIPTION:(IB)^2 common room 1C6.111 – Building B/C\, 6th floor\, La Plaine Campus\, ULB
URL:https://ibsquare.be/event/journal-club-jose-gavalda-garcia/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Brussels:20230303T120000
DTEND;TZID=Europe/Brussels:20230303T130000
DTSTAMP:20260418T185107
CREATED:20221129T091655Z
LAST-MODIFIED:20260318T130158Z
UID:1658-1677844800-1677848400@ibsquare.be
SUMMARY:Journal Club - Rossana Bettoni
DESCRIPTION:(IB)^2 common room 1C6.111 – Building B/C\, 6th floor\, La Plaine Campus\, ULB
URL:https://ibsquare.be/event/journal-club-rossana-bettoni-2/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Brussels:20230217T120000
DTEND;TZID=Europe/Brussels:20230217T130000
DTSTAMP:20260418T185107
CREATED:20221129T091617Z
LAST-MODIFIED:20260318T130209Z
UID:1656-1676635200-1676638800@ibsquare.be
SUMMARY:Journal Club - Robin Grolaux
DESCRIPTION:(IB)^2 common room 1C6.111 – Building B/C\, 6th floor\, La Plaine Campus\, ULB
URL:https://ibsquare.be/event/journal-club-robin-grolaux-2/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Brussels:20230203T120000
DTEND;TZID=Europe/Brussels:20230203T130000
DTSTAMP:20260418T185107
CREATED:20221129T091540Z
LAST-MODIFIED:20260318T130214Z
UID:1654-1675425600-1675429200@ibsquare.be
SUMMARY:Journal Club - Konstantina Tzavella
DESCRIPTION:(IB)^2 common room 1C6.111 – Building B/C\, 6th floor\, La Plaine Campus\, ULB
URL:https://ibsquare.be/event/journal-club-konstantina-tzavella-2/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Brussels:20230120T120000
DTEND;TZID=Europe/Brussels:20230120T130000
DTSTAMP:20260418T185107
CREATED:20221129T091408Z
LAST-MODIFIED:20260318T130229Z
UID:1651-1674216000-1674219600@ibsquare.be
SUMMARY:Journal Club - Joel Roca
DESCRIPTION:(IB)^2 common room 1C6.111 – Building B/C\, 6th floor\, La Plaine Campus\, ULB
URL:https://ibsquare.be/event/journal-club-joel-roca/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Brussels:20221209T120000
DTEND;TZID=Europe/Brussels:20221209T130000
DTSTAMP:20260418T185107
CREATED:20221129T091325Z
LAST-MODIFIED:20260318T130305Z
UID:1649-1670587200-1670590800@ibsquare.be
SUMMARY:Journal Club - Barbara Gravel
DESCRIPTION:
URL:https://ibsquare.be/event/journal-club-barbara-gravel-2/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20200306T150000
DTEND;TZID=Europe/Paris:20200306T160000
DTSTAMP:20260418T185107
CREATED:20200207T145953Z
LAST-MODIFIED:20200228T084347Z
UID:1058-1583506800-1583510400@ibsquare.be
SUMMARY:Seminar: Understanding of Plant Adaptation to Different Environment Conditions
DESCRIPTION:Understanding of Plant Adaptation to Different Environment Conditions \nBing CHENG \nAbstract: \nClimate change is threatening many agricultural regions around the globe. Plants are sessile organisms and migrate to more prosperous habitat. How do they approach this is an open question in plant science. This presentation will cover our recent studies exploiting plant phenotypic and genomic information\, to demonstrate how their deployment can help agriculture withstands climate change responsibly and sustainably. Results from these studies will provide insights into the genetic adaptation of plants in a wider range of available future environments. \nShort Bio: \nIn 2019\, Bing gained her PhD degree from The University of Queensland\, Australia under the supervision of Prof. R. Henry. She focused on the genetic improvement of coffee quality through comparative genomics and transcriptomics. She has published the first long-read reference transcriptome for Arabica coffee bean and identified candidate genes regulating essential chemical accumulation during bean ripening. Currently\, Bing Cheng is a postdoctoral fellow from the Crop Production and Biostimulation Laboratory (CPBL) at the Interfaculatry School of Bioengineers\, ULB\, under the guidance of Prof C. Hermans. She is exploiting the natural variability of the model (Arabidopsis) and crop (oilseed rape) species to decipher genetic bases of resource use efficiency\, using genome-wide association studies and global transcriptome analysis. \nAbout CPBL: \nThe Crop Nutrition unit at CPBL focuses on improving resource use efficiency of crops to ensure food security and environmental quality. A considerable fraction of fertilizer to sustain plant biomass production gets lost as runoffs with detrimental consequences to the environment and human health. Faced with those pressing societal costs\, modern agriculture must make a step change to produce biomass with less input. The unit develops synergistic activities in the laboratory\, natural habitat and field environments to identify plant characteristics for improving the resilience of agricultural production. \nThe core research theme developed at CPBL is on the environmentally sustainable intensification of the agricultural system. Research developed by the host group is interdisciplinary and aims at (i) identifying crop characteristics for improving resilience of agricultural production while limiting the environmental footprint\, (ii) providing breeders with selection criteria (including molecular and genomic tools) to develop new crop varieties\, (iii) developing and evaluating methods (in lab and field environments) for performance testing of these varieties.
URL:https://ibsquare.be/event/seminar-bing-cheng/
LOCATION:VUB I.1.05
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20200221T153000
DTEND;TZID=Europe/Paris:20200221T163000
DTSTAMP:20260418T185107
CREATED:20200207T145846Z
LAST-MODIFIED:20200212T161954Z
UID:1054-1582299000-1582302600@ibsquare.be
SUMMARY:Seminar Predicting Protein and RNA Structures via data inference
DESCRIPTION:Alexander Schug\nJohn von Neumann Institute for Computing\, Jülich Supercomputer Centre\, Forschungszentrum Jülich\nFaculty of Biology\, University of Duisburg-Essen \nPredicting Protein and RNA Structures via data inference \nOn the molecular level\, life is orchestrated through an interplay of many biomolecules. To gain any detailed understanding of biomolecular function\, one needs to know their structure. Yet the structural characterization of many important biomolecules and their complexes – typically preceding any detailed mechanistic exploration of their function- remains experimentally challenging. Tools rooted in statistical physics such as Direct Coupling Analysis (DCA) but also increasingly Machine Learning driven approaches take advantage of the explosive growth of sequence databases and infer residue co-evolution to guide structure prediction methods via spatial constraints. Going beyond anecdotal cases of a few protein families\, systematic large-scale studies of >1000 protein families are now possible and other information\, such as low-resolution experimental information from\, e.g. SAXS or FRET \, can be used as further constraints in simulations.
URL:https://ibsquare.be/event/seminar-alex-schug/
LOCATION:VUB I.1.05
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20191122T150000
DTEND;TZID=Europe/Paris:20191122T160000
DTSTAMP:20260418T185107
CREATED:20191024T190144Z
LAST-MODIFIED:20191108T130544Z
UID:967-1574434800-1574438400@ibsquare.be
SUMMARY:Seminar Simon Dellicour\, ULB
DESCRIPTION:Simon Dellicour\, ULB \nLandscape phylogeography – Using viral gene sequences to compare and explain the heterogeneous spatial dynamics of virus epidemics
URL:https://ibsquare.be/event/seminar-simon-dellicour-ulb/
LOCATION:VUB\, Building I\, I.0.01
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20190524T150000
DTEND;TZID=Europe/Paris:20190524T160000
DTSTAMP:20260418T185107
CREATED:20190118T141236Z
LAST-MODIFIED:20190522T125909Z
UID:883-1558710000-1558713600@ibsquare.be
SUMMARY:Journal Club: Sylvie
DESCRIPTION:Inverse problem : an application in brain imaging and in cancerology\nInverse problem is a class of models in which we try to determine the causes of a phenomenon from the experimental observations of its effects. During my presentation\, I will speak about two inverse problems that show similarities in their resolution. The first one is in magnetoencephalography where the goal is to find the activated brain regions thanks to measures of the magnetic field outside the skull. The second one is in cancerology where the goal is try to find the percentage of all cell types present in a tumor thanks to sequencing data.
URL:https://ibsquare.be/event/journal-club-sylvie/
LOCATION:(IB)² common room\, 1C6.111 - Building B/C\, 6th floor\, La Plaine Campus\, ULB
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20190510T150000
DTEND;TZID=Europe/Paris:20190510T160000
DTSTAMP:20260418T185107
CREATED:20190118T141101Z
LAST-MODIFIED:20190508T150100Z
UID:879-1557500400-1557504000@ibsquare.be
SUMMARY:Journal Club: Alex - Knowledge representations for contextualising disease associated molecular signatures
DESCRIPTION:
URL:https://ibsquare.be/event/journal-club-alex/
LOCATION:(IB)² common room\, 1C6.111 - Building B/C\, 6th floor\, La Plaine Campus\, ULB
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20190503T150000
DTEND;TZID=Europe/Paris:20190503T160000
DTSTAMP:20260418T185107
CREATED:20190327T155000Z
LAST-MODIFIED:20190329T124410Z
UID:935-1556895600-1556899200@ibsquare.be
SUMMARY:Seminar Thierry Mora (ENS\, Paris) - Diversity and response in immune repertoires
DESCRIPTION:The diversity of repertoires of B-cell and T-cell receptors is\ngenerated by a stochastic process of gene rearrangement called VDJ\nrecombination\, and is later sculpted by selection\, clonal\nproliferation\, and somatic hypermutations. I will show how these\nprocesses can be learned quantitatively from high-throughput\nrepertoire sequencing data. The resulting models can then be used to\nestimate the diversity of repertoires and their overlap between\nindividuals\, to identify condition-specific immune receptors from\npatient cohort data\, and to detect signatures of immune responses in\nsingle patients\, opening the way for novel sequencing-based diagnostic\nand prognostic tools.
URL:https://ibsquare.be/event/seminar-thierry-mora-ens-paris/
LOCATION:Solvay Room (ULB\, NO building 5th floor)\, Campus Plaine\, Bvd du Triomphe\, Brussels\, 1050
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20190405T150000
DTEND;TZID=Europe/Paris:20190405T160000
DTSTAMP:20260418T185107
CREATED:20190118T141021Z
LAST-MODIFIED:20190425T104521Z
UID:877-1554476400-1554480000@ibsquare.be
SUMMARY:Journal Club: Sofia
DESCRIPTION:In the era of the rise against statistical significance: what have we (not) learnt from millions of scientific papers with P-values
URL:https://ibsquare.be/event/journal-club-sofia/
LOCATION:(IB)² common room\, 1C6.111 - Building B/C\, 6th floor\, La Plaine Campus\, ULB
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20190322T150000
DTEND;TZID=Europe/Paris:20190322T160000
DTSTAMP:20260418T185107
CREATED:20190118T140938Z
LAST-MODIFIED:20190320T102816Z
UID:875-1553266800-1553270400@ibsquare.be
SUMMARY:Journal Club: Nathaniel and Rudy - "Cell movement\, chemotaxis\, and statistical physics"
DESCRIPTION:
URL:https://ibsquare.be/event/journal-club-nathaniel-rudy/
LOCATION:(IB)² common room\, 1C6.111 - Building B/C\, 6th floor\, La Plaine Campus\, ULB
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20190315T150000
DTEND;TZID=Europe/Paris:20190315T160000
DTSTAMP:20260418T185107
CREATED:20190118T140757Z
LAST-MODIFIED:20190313T095253Z
UID:871-1552662000-1552665600@ibsquare.be
SUMMARY:Seminar Zeynep Kalender Atak\, Heterogeneity of melanoma genomes and cell states (KUL)
DESCRIPTION:Heterogeneity in cancer is a consequence of both irreversible genetic changes and reversible transcriptional changes. Melanoma is prime example for this since on the genomic level melanomas have a high mutational burden leading to inter and intra-tumor heterogeneity while on the transcriptomic level they can be classified into two distinct but highly plastic transcriptional states (termed as proliferative and invasive) leading to intra-tumor heterogeneity. These states potentially play a role in metastasis\, therapy resistance and immune evasion\, thus understanding the mechanisms of this transcriptional plasticity is crucial. In my talk\, I will present our efforts for identifying molecular characteristics of these states using multi-omics approaches ranging from whole genome sequencing to bulk & single-cell transcriptome sequencing.
URL:https://ibsquare.be/event/seminar-zeynep-kalender-atak-heterogeneity-of-melanoma-genomes-and-cell-states-kul/
LOCATION:Forum F\, ULB
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20190308T150000
DTEND;TZID=Europe/Paris:20190308T160000
DTSTAMP:20260418T185107
CREATED:20190118T140856Z
LAST-MODIFIED:20190118T140856Z
UID:873-1552057200-1552060800@ibsquare.be
SUMMARY:Journal Club: Charlotte
DESCRIPTION:
URL:https://ibsquare.be/event/journal-club-charlotte/
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20190222T150000
DTEND;TZID=Europe/Paris:20190222T160000
DTSTAMP:20260418T185107
CREATED:20190118T140638Z
LAST-MODIFIED:20190219T104918Z
UID:868-1550847600-1550851200@ibsquare.be
SUMMARY:Seminar Rob Jelier (KUL) : Simulating Cellular Movements in Early C. elegans Embryogenesis
DESCRIPTION:Abstract: Understanding how cells position themselves correctly in multicellular environments is a fundamental challenge in developmental biology. We use the invariable embryogenesis of C. elegans and a modelling approach to better understand the underlying mechanisms driving cellular movements. We developed a simulator to model the physical interactions among cells that influence cell motion\, including physical constraints\, cell division\, adhesion\, and active forces. To inform and evaluate simulations we use a dataset of real embryos with microscopy tracked nuclei positions. In the model cells are represented as soft spheres that can repulse and adhere to each other\, and also move and divide. Cell division timings and movement directions are taken from the dataset. The egg shell repulses the cells and is modelled as a convex hull whose shape is derived from the embryo dataset. We use the model to unravel the contribution of purely physical processes in early embryogenesis\, such as the spatial constraints\, egg shape\, and shape changes due to divisions\, and active biological phenomena such as differential adhesion and active movements. The problem is framed as a machine learning approach to find the correct cellular positioning\, where hypotheses are evaluated by learning optimal parameter values on a training set and testing how much they improved cellular positioning. To optimize the model parameters we used evolutionary algorithms. Differential evolution is used for continuous variables and a novel molecule-based evolution scheme optimizes the differential cellular adhesion. At the 8-cell stage our simulations highlight previously described phenomena\, such as a weak basal adhesion force among all cells and active movements for the ABpl and ABpr cells. Also adhesion between E and P3 is suggested\, which matches published results of how descendants of both cells adhere during gastrulation. Our main goal however is to reproduce the complex movements during the AB64 stage. We are currently evaluating our predictions for this phase with experimens\, by visualizing e-cadherin molecules\, cell shapes and the actomyosin network. As a perspective\, we are expanding our simulator with a signaling model. Cell signaling is represented as a network of reactions expressed as logic rules\, where signals trigger cascades and determine cell fate. By modelling how signals affect fate\, linking fate to cell behavior\, we can predict the effects of perturbations on cell fates and positions.
URL:https://ibsquare.be/event/seminar-rob-jelier-kul/
LOCATION:Forum F\, ULB
CATEGORIES:Seminar
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20190215T150000
DTEND;TZID=Europe/Paris:20190215T160000
DTSTAMP:20260418T185107
CREATED:20190118T140515Z
LAST-MODIFIED:20190208T110533Z
UID:866-1550242800-1550246400@ibsquare.be
SUMMARY:Seminar Genevière Dupont (ULB) - Intracellular calcium dynamics: from modeling to physiology
DESCRIPTION:
URL:https://ibsquare.be/event/seminar-geneviere-dupont-ulb/
LOCATION:Forum F\, ULB
CATEGORIES:Seminar
END:VEVENT
END:VCALENDAR