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Seminar Thierry Mora (ENS, Paris) – Diversity and response in immune repertoires
3 May 2019 @ 15 h 00 min - 16 h 00 min
The diversity of repertoires of B-cell and T-cell receptors is
generated by a stochastic process of gene rearrangement called VDJ
recombination, and is later sculpted by selection, clonal
proliferation, and somatic hypermutations. I will show how these
processes can be learned quantitatively from high-throughput
repertoire sequencing data. The resulting models can then be used to
estimate the diversity of repertoires and their overlap between
individuals, to identify condition-specific immune receptors from
patient cohort data, and to detect signatures of immune responses in
single patients, opening the way for novel sequencing-based diagnostic
and prognostic tools.